Clinical Evidence

Publications & Manuscripts

Extracorporeal Ultrafiltration for Fluid Overload in Heart Failure : Current Status and Prospects for Further Research

Maria Rosa Costanzo, MD, et al. | Journal of American College of Cardiology

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Early Ultrafiltration in Patients With Decompensated Heart Failure and Diuretic Resistance

Maria Rosa Costanzo, MD, et al. | Journal of American College of Cardiology

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Ultrafiltration Versus Usual Care for Hospitalized Patients With Heart Failure

Bradley A. Bart, MD, et al. | Journal of American College of Cardiology

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Peripherally inserted veno-venous ultrafiltration for rapid treatment of volume overloaded patients

Brian E. Jaski, MD, et al. | Presented at HFSA 2002

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Circulatory Response to Fluid Overload Removal by Extracorporeal Ultrafiltration in Refractory Congestive Heart Failure

GianCarlo Marenzi, MD, et al. | Journal of American College of Cardiology

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Sustained Improvement in Functional Capacity After Removal of Body Fluid with Isolated Ultrafiltration in Chronic Cardiac Insufficiency: Failure of Furosemide to Provide the Same Result

Piergiuseppe Agostoni, MD, et al. | American Journal of Medicine

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Sustained Cardiac Diastolic Changes Elicited by Ultrafiltration in Patients with Moderate Congestive Heart Failure: Pathophysiological Correlates

Mauro Pepi, MD et al. | British Heart Journal

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Isolated Ultrafiltration in Moderate Congestive Heart Failure

Piergiuseppe Agostoni, MD, et al. | Journal of American Cardiology

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Hemofiltration During Cardiopulmonary Bypass for High Risk Adult Cardiac Surgery

Raman JS, MD, et al. | International Journal of Artificial Organs

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Treatment Guidelines

2013 ACCF/AHA Guideline for the Management of Heart Failure

Clyde W. Yancy, MD, et al. | 2013 ACCF/AHA

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Page 48 of document (Section 8.5) reviews Renal Replacement Therapy – Ultrafiltration Recommendations. Page 50 of document; Table 28 – Recommendations for Therapies in the Hospitalized HF patient).

Fonarow GC, Geraci SA, Horwich T, Januzzi JL, Johnson MR, Kasper EK, Levy WC, Masoudi FA, McBride PE, McMurray JJV, Mitchell JE, Peterson PN, Riegel B, Sam F, Stevenson LW, Tang WHW, Tsai EJ, Wilkoff BL. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013;128:e240–e327.

Rx Only

Indication: The Aquadex FlexFlow® System is indicated for temporary (up to 8 hours) ultrafiltration treatment of patients with fluid overload who have failed diuretic therapy; and extended (longer than 8 hours) ultrafiltration treatment of patients with fluid overload who have failed diuretic therapy and require hospitalization. All treatments must be administered by a healthcare provider, under physician prescription, both of whom having received training in extracorporeal therapies.